In brain tissue, a biochemical cascade known as the ischemic cascade is triggered when the tissue becomes ischemic, potentially resulting in damage to and death of brain cells. Too little blood flow (ischemia) results in tissue death. Too much blood can raise intracranial pressure (ICP), which can compress and damage delicate brain tissue. CBF is tightly regulated to meet the brain’s metabolic demands. In an adult, CBF is typically 750 milliters per minute or 15% of the cardiac output. The amount of blood that the cerebral circulation carries is known as cerebral blood flow (CBF). Failure of these safeguards results in cerebrovascular accidents, commonly known as strokes. The circle of Willis, a circulatory anastomosis that supplies blood to the brain and surrounding structures while providing redundancy in case of any interruption, is a key protection. Since the brain is very vulnerable to compromises in its blood supply, the cerebral circulatory system has many safeguards. The arteries deliver oxygenated blood, glucose, and other nutrients to the brain and the veins carry deoxygenated blood back to the heart, removing carbon dioxide, lactic acid, and other metabolic products. intracranial pressure: The pressure inside the skull.Ĭerebral circulation refers to the movement of blood through the network of blood vessels supplying the brain.cerebral blood flow: The blood supply to the brain in a given time period.ischemia: An inadequate blood supply to an organ or part of the body.\)Ĭerebral circulation is the movement of blood through the network of blood vessels supplying the brain, providing oxygen and nutrients.
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